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Avastin Study Misses Endpoint In Early-Stage Colon Cancer

Genentech's Phase III study of Avastin (bevacizumab) plus chemotherapy in patients with early-stage colon cancer (NSABP C-08) did not meet its primary endpoint of reducing the risk of cancer returning.

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By: Tim Wright

Editor-in-Chief, Contract Pharma

Genentech’s Phase III study of Avastin (bevacizumab) plus chemotherapy in patients with early-stage colon cancer (NSABP C-08) did not meet its primary endpoint of reducing the risk of cancer returning (improvement in disease-free survival). This is the first trial of Avastin in early-stage cancer and results do not affect approved indications in advanced (metastatic) disease. “While we are disappointed the C-08 study did not meet its primary endpoint, our initial review of the data lead...

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